
The cap F being removed, the capping end of the plunger is run up through the chamber H, its foot occupying the upper portion of section 7 and the feathers g g in the grooves d d. The upper end of the plunger is provided with a cap, F, secured thereto by the screwconnection f. The plunger F, which is intended to be moved up and down in the chamber H, consists of a cylindrical metal rod, having at its base an enlargement or foot, 8, which latteris provided on opposite sides with the feathers g g. Lower section, 7, being furnished with the staple-grooves d (I, cut vertically in its opposite sides.


238000006011 modification reaction Methods 0.000 description 3.Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.) Expired - Lifetime Application number Publication date Application granted granted Critical Publication of US212316A publication Critical patent/US212316A/en Anticipated expiration legal-status Critical Status Expired - Lifetime legal-status Critical Current Links

Replacing l-arginine with radiosensitizers, photosensitizers, and photothermal agents may make ACSL a universal platform for the rapid development of various combinations of anticancer therapies.US212316A - Improvement in devices for inserting metallic staples in papers - Google Patents US212316A - Improvement in devices for inserting metallic staples in papers - Google Patents Improvement in devices for inserting metallic staples in papers Download PDF Info Publication number US212316A US212316A US212316DA US212316A US 212316 A US212316 A US 212316A US 212316D A US212316D A US 212316DA US 212316 A US212316 A US 212316A Authority US United States Prior art keywords staple anvil plunger case face Prior art date Legal status (The legal status is an assumption and is not a legal conclusion. l-arginine encapsulated in ACSLs induces robust T cell-dependent antitumor response and immune memory in 4T1 tumor-bearing mice after local irradiation, resulting in significant tumor suppression and an abscopal effect. The ACSLs capture and transport TAAs from lysosomes to the cytoplasm in DCs, thereby enhancing TAA cross-presentation. Herein, an antigen-capturing stapled liposome (ACSL) with a robust structure and bioactive surface is developed. Importantly, TAAs internalized by DCs are easily degraded in lysosomes, resulting in unsatisfactory extent of TAA cross-presentation.

However, the irradiation resistance of tumor cells usually results in limited TAA generation and release. The release of tumor-associated antigens (TAAs) and their cross-presentation in dendritic cells (DCs) are crucial for radio-immunotherapy.
